PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB signaling
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چکیده
Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China, ICORP/SORST Cell Mechanosensing, JST, 65 Tsurumai, Nagoya 466-8550, Japan, Department of Physiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Nagoya 466-8550, Japan, Department of Aging Intervention, National Institute for Longevity Sciences, Oobu 474-8522, Japan, Department of Anatomy and Neurobiology, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan, Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
منابع مشابه
PREGS Induces LTP in the Hippocampal Dentate Gyrus of Adult Rats Via the Tyrosine Phosphorylation International Cooperative Research CREB Signaling
Ling Chen, Yoshiaki Miyamoto, Kishio Furuya, Nozomu Mori, and Masahiro Sokabe Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; International Cooperative Research Project/Solution Oriented Research for Science and Technology Cell Mechanosensing, JST, Nagoya; Department of Physiology, Nagoya University Graduate School of Medicine, Nagoya; Department of Aging Interv...
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Tyrosine kinase phosphorylation plays an important role in the induction of long-term potentiation (LTP). Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that shows decreased phosphorylation in fyn mutant mice, and Fyn plays a critical role in LTP induction. By examining the role of FAK involved in LTP induction in dentate gyrus in vivo with medial perforant path stimulatio...
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A great deal of recent evidence points to a role for tyrosine kinase in expression of LTP. Data have been presented that are consistent with the idea that tyrosine phosphorylation of proteins occurs in both the presynaptic and postsynaptic areas. In this study, we set out to investigate the role that tyrosine kinase might play presynaptically to modulate release of glutamate in an effort to und...
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Both serine/threonine and tyrosine phosphorylation of receptor proteins have been implicated in the process of long-term potentiation (LTP), but there has been no direct demonstration of a change in receptor phosphorylation after LTP induction. We show that, after induction of LTP in the dentate gyrus of anesthetized adult rats, there is an increase in the tyrosine phosphorylation of the 2B sub...
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The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade contributes to synaptic plasticity and to long-term memory formation, yet whether MAPK/ERK controls activity-dependent gene expression critical for long-lasting changes at the synapse and what the events underlying transduction of the signal are remain uncertain. Here we show that induction o...
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تاریخ انتشار 2007